Academic Medical Centers: A Triple Threat Approach to Leveraging Healthcare Analytics

With its combined medical center, research, and education arms, the academic medical center (AMC) is a uniquely resource-rich member of the healthcare industry. However, despite this expansive access, AMCs still need more effective strategies to merge their disparate data and use that information to improve their complex mission—from delivering quality care and furthering medical research to educating tomorrow’s health care leaders.

We sat down with Dale Sanders, Health Catalyst Chief Technology Officer, to learn more about the role healthcare analytics plays in academic medicine, now and in the future, and how AMCs can better leverage these analytics as a strategic asset.

Let’s start with the big question, then explore the details. What’s next for the academic medical center in the healthcare analytics landscape?

Four big things come to mind. First, is this paradoxical explosion of both genomic knowledge and genomic ignorance. The more we learn, the more we don’t understand. But we have to keep exploring and integrating genomic and clinical data spaces.

Second is the microbiome. If we think genomics and epigenetics are mysterious, the microbiome will make that mystery look like a nursery rhyme.

Third is the need to digitize the patient beyond the data we collect in a clinical or hospital encounter. We have to think more like electrical and aeronautical engineers who understand digital sampling theory, and aircraft and spacecraft health maintenance. This is the world of biointegrated sensors, like the work of John Rogers at Northwestern.

Fourth, I believe that the inherent needs of population health and the inherent cultural infrastructure of AMCs are a mismatch made in heaven, and that mismatch will end in divorce in the overwhelming majority of cases. Population health concepts are incredibly difficult to achieve in any case, as evidenced by the lack of measurable and sustainable success stories, but in AMCs it’s even harder. Everything about an AMC, from the ground up, is about novel research, and treatment of complex and unusual cases—not prevention and engagement with chronic disease patients that spans years, if not decades. I might even offer the provocative opinion that we, as patients and taxpayers, should discourage AMCs from engaging in population health so they can return focus to their core strengths, and leave population health to community hospitals and integrated delivery networks. Rare disease research, treatment, and prevention is a classic opportunity for AMCs to exert their fundamental strength, but population health is pushing aside rare and genetic diseases. I predict, with a pinch of hope, that AMCs will reduce their attempts to become experts in population health and revert back to their strengths or shift quickly to become an IDN like Partners and the University of Texas Health System. Either of those shifts will require a shift in healthcare data and analytic strategies.

The strategic options for AMCs to meet their future analytics and application development needs come down to the usual choices. They can build their own, which I don’t recommend. Those days are over. They can rely on their core EHR vendor because that’s the easy choice, and they’ve already spent a boatload of money on that vendor. The jury is still out as to whether the EHR vendors can turn themselves into data operating systems. It will take a major technical and cultural change for them to do that. And finally, AMCs can choose a data-first platform company like Health Catalyst. I honestly don’t know of another company like Health Catalyst that has the combination of healthcare-focused data technology with healthcare-focused domain expertise. One of the limiting factors to more companies existing in this space is the shear financial investment required to build the underlying technology, combined with the acquisition of knowledge of healthcare operations. It’s incredibly hard and unlikely to recreate what we’ve built at Health Catalyst.

What role do healthcare analytics play in digitizing a patient’s healthcare journey?

Leaders in academic medicine are just beginning to recognize  the effort to digitize the patient and the patient’s healthcare. It will be a 10- to 20- year journey to robust maturity and will never completely end. The technological platform that supports the digitization of the patient must be able to evolve gracefully over a similar period of time.

How can the patient data ecosystem help AMCs better leverage data?

AMCs must develop a strategic data acquisition strategy that accounts for the roadmap and methods for collecting and leveraging the data depicted in Figure 1. I drew this cartoon in 2008, when I was at Northwestern, to represent the general categories of data necessary to fully understand the patient at the center.

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Figure 1: The patient data ecosystem.

For the most part, the data in the lower left quadrant of the drawing currently characterizes the realm of healthcare data and analytics. That’s where most of our data and analytics focus in healthcare currently resides. While that data content is certainly better than nothing, and can produce significant analytic value, it’s not enough to deliver personalized, precision medicine, one patient at a time. Population health is an inherently data-driven concept that begins one patient at a time, from the ground up, not from the top down.

What can AMCs use to guide their data and healthcare analytics journey?

With invaluable help from many friends and colleagues, I co-published the Healthcare Analytics Adoption Model (Figure 2) in 2012 with Dr. Denis Protti of the University of Victoria-British Columbia. The model, and the details behind it, can be used to evaluate vendors, inform product roadmaps, and assess an organization’s state of analytic maturity. We granted its use to the Health Information Management Systems Society under creative commons copyright so that they could use it to conduct independent assessments, much like the service that they provide with the EMR Adoption Model.

 

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Figure 2. The Healthcare Analytics Adoption Model.

The common problem we see in healthcare, especially in AMCs, is the tendency to pursue analytics at the upper levels while neglecting the lower levels of the model. Organizations often find themselves incapable of sustaining or scaling the analytics in those upper levels. By progressively working through each level of this model, AMCs can operate efficiently and sustainably at the upper levels.

At Level 1, your analytics model suggests the need for an Enterprise Data Operating System. Talk about that.

I call it the Data Operating System (DOS™) because the concept is more than a traditional data warehouse; the DOS concept supports analytics, application development, and record-level exchange of data, all from a single platform of consistent and reusable data.

Multiple, traditional data warehouses are common at AMCs. Typically, one of those data warehouses is centrally funded and managed to support healthcare operations, compulsory measures, and administrative management. Several other data warehouses typically exist and were born out of research grants. In addition to the costs associated with maintaining these redundant systems, their missions and data content become redundant, and even competitive, and create significant data governance problems. At Northwestern, we designed a single enterprise data warehouse to support all three missions of the AMC—education, research, and care delivery. We brought the lessons of that success story to influence at Health Catalyst and DOS. Gartner calls it a Hybrid Transaction/Analytical Processing architecture.

AMCs suffer from physician burnout. Are healthcare analytics the solution or the problem?

Right now, healthcare analytics and data are both the solution and the problem. Academic medicine suffers from the same problems of physician burnout, and maybe worse, that currently affect the rest of industry. There are a number of reasons behind burnout, but we believe the overwhelming demand on clinicians to support compulsory quality measures through data collection drives a significant portion. Many of these compulsory measures lack clinical relevance, so a physician’s clinical performance is ironically measured by the same irrelevant data points that burden clinicians. It’s a vicious cycle that strips away their sense of autonomy and mastery over their profession.

Because of the murky connection tying compulsory quality measures to clinical performance, Health Catalyst strongly advocates an analytics strategy that openly admits to the flaws in these compulsory measures while acknowledging the reality they currently play in economic reimbursement. Financially, they can’t be ignored. The strategy then, must reduce the burden for collecting this data and producing the related analytics through technology, while at the same time providing clinicians the data they want and need, when they need it, in the form they need it.

Several AMCs have home-grown analytics systems based on big data technology. How’s that turning out?

The public cloud makes big data technology—e.g., the Hadoop ecosystem, Spark, and NoSQL databases—particularly appealing to many AMCs. In my opinion and observation, the AMCs that jumped early into big data are not realizing the enterprise value and scalability they expected. Beyond the world of genomics, big data has had a small, and sometimes negative, ROI to healthcare analytics. Initially, the world of big data was portrayed as the replacement of traditional relational databases, but that has not been the case. Health Catalyst designed DOS keeping in mind that the worlds of big data and relational databases are now blending together into a hybrid architecture that leverages the best of both worlds.

How can AMCs ensure their precision medicine efforts reach beyond the lab?

It depends on how you define precision medicine, but if it’s delivering care protocols that are tailored to a patient’s genomic profile and understanding the phenotypic expression of disease based on clinical profiles, then yes, we’re talking about the same thing. Virtually all AMCs now engage in some form of precision medicine research. So far, however, precision medicine is not reaching patient care. In part, today’s EHRs make it very difficult, at best, to blend the synthesis of genomic and traditional clinical data together at the point of decision making. But, we can still work on the discovery of insights while we work on improving the delivery of insights. With DOS, or a similar platform, we can support the exploration of phenotyping in three different models:

  1. Extracting clinical operations data and text and blending it with omics data in a separate target platform.
  2. Extracting omics data from a separate source system and blending it with operational data and text in the DOS target platform.
  3. Consolidating and blending omics and operational data and text into a single platform under DOS.

What about text and natural language processing?

The traditional approaches to natural language processing (NLP) in healthcare have not produced any widespread or sustainable value. I’ve watched it flounder for 25 years. So, like precision medicine, the value of NLP has not yet reached patient care, but we believe the next evolution of NLP will, as the focus of NLP shifts from attempts to extract discrete values from text, to a pattern recognition-based approach to analyzing clinical notes. We designed DOS as a platform that integrates discrete and text data in a single infrastructure, making the integration of discrete and text data a standard best practice.

As a platform that was designed specifically to support third-party application development, DOS enables vendors who specialize in NLP to plug their applications into the DOS infrastructure and leverage the DOS investment at client sites—rather than building, and clients paying for, another platform. Health Catalyst products leverage text data to support narrow domains of decision support and NLP use cases, such as those associated with our Patient Safety Monitor™ Suite: Surveillance Module.

While we’re on the theme of heavily-hyped topics, what about artificial intelligence?

Again, it sort of depends on how you define artificial intelligence (AI). My definition and views on AI go back to the early 1990s when I was working in the space, defense, and intelligence sector. At the fundamental level, AI is all about computerized pattern recognition and then responding or intervening according to the pattern. Sometimes the response is generated by the computer, sometimes the response to the pattern is generated by a human’s interpretation and brain.

In any case, the precision of the pattern drives the precision of the response. More data equals a more precise pattern, which equals a more precise response. Effective AI is directly proportional to the rows and columns, or “features,” available to train the models. Data volume and granularity matter, but data volume and granularity in healthcare is quite low when it comes to the digital understanding of patients’ health status—as evidenced by the struggles of IBM Watson.

There are no corpora of knowledge in healthcare equivalent to the collection of knowledge that made Watson successful on Jeopardy. My healthcare provider, and probably your healthcare provider, too, only collects data on me about once per year, or less. That’s not enough of a data sample to inform a precise AI model. One of the most important missing data elements, in terms of value to AI, is patient-reported outcomes. Without patient-reported outcomes, the most valuable AI algorithms to patient care are left in an open-loop status.

We see many AMCs developing their own AI models, particularly predictive models, but lacking the interventions that make them effective. I advocate a pragmatic approach to AI hype, working within the realities of healthcare analytics, up to the leading edge of AI, but not beyond it, where hype exceeds reality.

There are three general categories in which AI can be applied at AMCs: First is imagery analysis, and that’s where hype and reality are most likely to coincide. Second is administrative functions, like rev cycle, billing and supply chain management; there is a lot of untapped opportunity there. Third, and the most overhyped and challenging, is clinical diagnosis and treatment recommendations. In this third area, we are overwhelmed in the industry with clinical risk predictive models, but risk predictions without suggestions for intervention are a liability to the decision maker, not an asset.

At Health Catalyst, we have a library of 20 to 25 predictive models covering topics like patient risk stratification, readmissions predictions, and propensity to pay predictions, so we’re in the game like everyone else. But, we are actively working on AI models to support informed interventions, not just predictions. We’re also building tools to help choose the best AI models for a desired outcome and evaluate all the traditional tradeoffs between sensitivity, specificity, and all that. In any case, we’ve designed DOS to evolve naturally, as the volume and type of data to feed AI models expands, and we’re designing new features in DOS to support the development, deployment and maintenance of AI models in one environment, applying DevOps concepts to AI applications.

The big buzz phrases in pharma are “real-world data” and “real-world evidence.” What do they really mean?

AMCs are at the center of this, given their role in clinical trials, device and drug development, etc. What these buzz words really means is, pharma now recognizes that they need to improve their reputation and value proposition; and towards that end, they need data from real-world healthcare operations, not just clinical trials.

The love-hate relationship between the pharma life sciences industry and academic medicine is as old as the first pill. Skyrocketing pharmaceutical costs and a growing distrust towards the pharma industry indicates that healthcare needs to improve for the sake of the patient. From a data perspective, the two worlds need to come together, and the motive for coming together around data can’t be more revenue or profit; there’s no more money left in the economy. It has to be about healthcare value to the patient.

We, Health Catalyst, started a Life Sciences business line that is committed to bringing the pharma and device industries closer to the frontlines of healthcare outcomes by bridging the data trust gap between pharma, providers, and patients. With our healthcare operations background, Health Catalyst can turn real-world evidence into real-world action that directly improves patient outcomes. By bringing pharma and AMCs together through analytics and as a trusted intermediary, we can improve clinical trial design and execution, stimulate clinical innovation, support population health through medication adherence, health economics, and outcomes research; reduce pharmaceutical costs by optimizing prescribing and adherence; and improve drug safety and pharmacovigilance.

What are some guidelines for AMCs to consider when selecting a future healthcare analytics platform?

In addition to the Analytics Adoption Model, AMCs can use what I’ve described as “The Seven Attributes of a Data Operating System” as a framework for assessing their ability to build their own or evaluate vendors. We defined the attributes as a means of distinguishing a “data operating system” from a data warehouse.

The following are the seven attributes of a data operating system:

    1. Reusable clinical and business logic: This is registries, value sets, and other data logic that lies on top of the raw data and can be accessed, reused, and updated through open APIs, enabling third-party application development.
    2. Streaming data: This is about providing real-time data streaming from the source all the way to the expression of that data through DOS, including support for transaction-level exchange of individual records of data.
    3. Integrated structured and unstructured data: Historically, data warehouses were designed to store and analyze discrete data, but a DOS must be capable of storing, analyzing, and sharing text and other non-discrete data, including images.
    4. Closed-loop capability: The analytic and decision support knowledge derived from DOS processing must be capable of bending back into the workflow of decision making, especially in EHRs. We call this closed-loop analytics, and it implies the need for APIs to make it possible and scalable.
    5. Microservices architecture: In the old days, we called this loosely coupled services. The concepts are exactly the same. That is, your software and APIs must be designed to support micro-level updates on a continuous delivery basis, as opposed to the massive annual upgrades characterized by tightly coupled healthcare software applications today. These microservices must also be designed from the beginning to enable building third-party applications on top of DOS.
    6. Machine learning: AI and machine learning must be considered a native function, not a bolt-on afterthought to meet the definition of a data operating system. That is, the development, test, deployment, and maintenance of AI models must look and feel like just another data-first software application.
    7. Agnostic data lake: This is by far the hardest of the seven criteria to satisfy. It requires the ability of the APIs, data logic, and AI models to be reasonably portable from one data lake to another. In other words, loosely coupled to the data lake and data source. The reusable forms of logic must support different computation engines, for example SQL, Spark SQL, and SQL on Hadoop, etc.

In addition to meeting these attributes, AMCs will also need to build or acquire a few other important capabilities:

  • A library of source data connectors: AMCs can expect to ingest data from up to 200 sources within three years of the initial operational capability of an analytics platform. The source data connector libraries are unique to the technology, data content, and data model of the system supplying the data. One of the most challenging aspects in developing these libraries is understanding and accommodating the data model and the change data capture strategy for these systems.
  • A measures content management system: There are over 2,000 compulsory measures in the U.S. healthcare environment, making it a challenge to keep track of the measures and their definitions. Quite often, mistakes occur that lead AMCs to submit inaccurate data to regulatory and reimbursement To reduce the labor and mistakes associated with managing compulsory measures, Health Catalyst developed a content management system called Measures Manager. Health Catalyst maintains a significant portion of this content according to the standards defined by CMS. Our clients can also use this content management system to manage their local definitions.
  • Tools for data pipeline development and management: A data pipeline development and management tool is a standard requirement for developing and maintaining any analytics platform. Vendors can purchase or build their own pipelines. Health Catalyst built its own data pipeline to avoid the high licensing fees associated with other tools, but also to provide a tool uniquely designed to support healthcare data management.
  • A metadata manager: A metadata management tool allows data analysts to browse the contents of the analytics platform in much the same way that a card catalog system allows patrons of a library to browse the contents of the library—at a meta level.
  • An operations console: The operations console monitors and helps maintain the health of the analytics platform and is critical to its long-term performance, availability, reliability, maintainability, and scalability (PARMS).
  • An analytics homepage: The analytics team will need a storefront webpage that describes all the products and services associated with the organization’s analytics mission and provides customer support, from handling requests for data and/or analytics services to completing order requests. The homepage also serves as a training resource for customers.
  • Curated data content: Curated data content facilitates consistent and reusable analytics. This data should be curated around two dimensions—standardized vocabulary and standardized data logic. Health Catalyst data engineers, for example, provide and maintain a significant layer of curated data models called DOS Marts.
  • Software APIs: Historically, analytics platforms have not leveraged APIs, but today it’s becoming a best practice to ensure the highest level of scalability and maintainability. Health Catalyst provides over 20 APIs, including a growing number associated with FHIR, to enable faster and more efficient analytics and application development. These APIs benefit application development for Health Catalyst engineers, clients, and third-parties.
  • Analytics and workflow applications: Up to this point, I’ve been talking mostly about infrastructure, but the point of all that infrastructure is to enable massively scalable analytics and application development. AMCs must either develop these on their own or choose a vendor that’s already built them. Building these is no small effort, even with the infrastructure underneath it. Health Catalyst has a catalog of about 60 analytics applications and about a dozen data-first software applications, including embedded AI models. In addition to the development of native web applications, the analytics team will need to support at least one, if not more, BI tools in the analytics ecosystem.
  • Closed-loop to the EHR: As I mentioned earlier, it’s not enough for the analytics team to provide decision support in conference rooms. Analytic decision support must make it to the edges of the organization and into the workflow of clinicians and their teams. At Health Catalyst, we call the enabling APIs for EHR integration, “Mosaic.”
  • Privacy and security: Analytic platforms, by nature, aim to provide deep and wide access to a variety of data. However, the dominant privacy and security models and best practices in healthcare are designed around EHRs. Building the underlying technology to enable flexible, configurable privacy and security is no small task.

How would you “future proof” the AMC healthcare analytics strategy and platform to support new technologies?

Modern architectures and design patterns have made future proofing significantly easier. Many of the systems I designed for the space and defense sector over 30 years ago are still in operation today, slowly evolving, piece by piece, never going through a total rip and replace. Likewise, the EDWs that we designed at Intermountain Healthcare and Northwestern Medicine, in 1998 and 2006 respectively, are still operating.

A modern analytics platform, such as DOS, supports a modular evolution of each component, following the best practices of systems engineering that exist today. We are confident that our version of DOS will be operating and thriving at client sites 25 years from now.

Additional Reading

Would you like to learn more about this topic? Here are some articles we suggest:

  1. Healthcare Analytics Adoption Model
  2. 5 Reasons Healthcare Data Is Unique and Difficult to Measure
  3. 7 Essential Practices for Data Governance in Healthcare
  4. Late-Binding™ Data Warehouse
  5. The Late-Binding™ Data Warehouse: A Detailed Technical Overview
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