Sepsis Prevention

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Product Overview

The Sepsis Improvement application is aimed at clinical and medical directors, operational directors, clinical program guidance teams in emergency, intensive care, and inpatient units. The application focuses on providing data to help improve early recognition of sepsis, early intervention for severe sepsis, and early therapy for septic shock to reduce mortality, morbidity, and cost.


  • Performance dashboard to visualize outcome and process metrics in an easy-to-consume, one-page performance summary.
  • Outcome metrics include mortality, 30-day readmission, LOS, ICU LOS, and cost per case.
  • Performance metrics include 3-hour bundle (lactate measurement, fluid resuscitation, blood culture, broad spectrum antimicrobial administration, all within 3 hours of time zero) and 6-hour bundle (vasopressor for initial fluid bolus resistant hypotension and for ongoing shock, measurement of CVP/ScvO2, remeasure of serum lactate within 6 hours of time zero) for compliance measurement.
  • In addition to compliance metrics (% of patient lactate measured with 180 min.), includes improvement metrics (% of patients with lactate measured within 1 hour of triage) so that clinical improvement feedback is available to understand specific performance gaps and what actions or interventions will be most effective.
  • Detailed analytics for each bundle domain provide dynamic data exploration, real-time filtering, and drill-down to patient level detail.
  • Includes visualizations to support understanding of how performance can be improved in bundle compliance to lower sepsis mortality rates.
  • Provides export or print capability for patient list, metric performance, etc.


Benefits Include:

  • Improved processes and timeliness of early recognition and treatment of sepsis.
  • Increased compliance to components of early intervention and early therapy guidelines.
  • Decreased mortality rate and length of stay.

See Sample Screenshots of Sepsis Prevention

Data Sources

  • EMR

Sepsis: A Deeper View


Sepsis has the highest mortality rate and cost of any condition treated in U.S. hospitals, and causes significant morbidity. One in four patients with severe sepsis or septic shock will die from the condition, and many of these deaths will occur in the hospital (Dellinger 2013). The hospital mortality rate for sepsis is more than 8 times higher than for any other diagnosis (Liu 2014). Sepsis also poses a huge economic burden to the US health system, accounting for over 5% of the total aggregate cost of all hospitalizations (Torio 2011).

What types of problems do Sepsis Advanced Application address?

Health Catalyst ranks the sepsis care process in the top one-third of its list of clinical quality improvement opportunities based on volume, variation, and financial metrics. The substantial evidence base to guide care also makes sepsis a promising area for quality improvement. To pursue opportunities to improve sepsis care and outcomes, organizations benefit from analytics that provide views of key metrics associated with clinical best practice, high-level performance measures, and transitions in patients’ care.

Use Case

  • Quality improvement leaders in a large hospital system observe that their sepsis mortality rate has been creeping upward over the previous three quarters—and seems to correspond to declining compliance with the ED screening protocol. Is declining compliance a problem at every facility’s ED, for all shifts?
  • The ED manager notes that compliance with the 3-hour bundle remains low, despite focused efforts to improve. Which aspect of the bundle is proving most problematic for front-line staff?

Anticipated Improvements

  • Improved processes and timeliness of early recognition and treatment of sepsis.
  • Increased compliance to components of early intervention and early therapy guidelines.
  • Decreased mortality rate and length of stay.

Success Measure Examples

Opportunity Identification:

  • Increase percent of patients eventually diagnosed with sepsis who were accurately diagnosed in the ED.

Process Improvements:

  • Lower time from ED triage to sepsis recognition and alert.
  • Increase percent of patients with severe sepsis for whom all components of the 3-hour early intervention bundle are met.
  • Increase percent of patients with septic shock for whom all components of the 6-hour early therapy bundle are met.

Outcomes Improvement:

  • Lower mortality rate for sepsis patients.
  • Reduce length of stay.